Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Among moral attributes true virtue alone is sublime. … [I]t is only by means of this idea [of virtue] that any judgment as to moral worth or its opposite is possible. … Everything good that is not based on a morally good disposition … is nothing but pretence and glittering misery. 1.

This is the most important book on Hegel to have appeared in the past ten years. The author offers a completely new interpretation of Hegel's idealism that focuses on Hegel's appropriation and development of Kant's theoretical project. Hegel is presented neither as a pre-critical metaphysician nor as a social theorist, but as a critical philosopher whose disagreements with Kant, especially on the issue of intuitions, enrich the idealist arguments against empiricism, realism, and naturalism. In the face of the dismissal of (...) absolute idealism as either unintelligible or implausible, Pippin explains and defends an original account of the philosophical basis for Hegel's claims about the historical and social nature of self-consciousness and of knowledge itself. (shrink)

" In Democratic Hope, Robert B. Westbrook examines the varieties of classical pragmatist thought in the work of John Dewey, William James, and Charles Peirce, ...

'Modernity' has come to refer both to a contested historical category and to an even more contested philosophical and civilisational ideal. In this important collection of essays Robert Pippin takes issue with some prominent assessments of what is or is not philosophically at stake in the idea of a modern revolution in Western civilisation, and presents an alternative view. Professor Pippin disputes many traditional characterisations of the distinctiveness of modern philosophy. In their place he defends claims about agency, freedom, (...) ethical life and modernity itself, all of which are central to the German idealist philosophical tradition, and in particular, to the writings of Hegel. Having considered the Hegelian version of these issues the author explores other accounts as found in Habermas, Strauss, Blumenberg, Nietzsche, and Heidegger. (shrink)

With the rise of review sites and social media, films today, as soon as they are shown, immediately become the topic of debates on their merits not only as entertainment, but also as serious forms of artistic expression. Philosopher Robert B. Pippin, however, wants us to consider a more radical proposition: film as thought, as a reflective form. Pippin explores this idea through a series of perceptive analyses of cinematic masterpieces, revealing how films can illuminate, in a concrete manner, (...) core features and problems of shared human life. Filmed Thought examines questions of morality in Almodóvar’s Talk to Her, goodness and naïveté in Hitchcock’s Shadow of a Doubt, love and fantasy in Sirk’s All That Heaven Allows, politics and society in Polanski’s Chinatown and Malick’s The Thin Red Line, and self-understanding and understanding others in Nicholas Ray’s In a Lonely Place and in the Dardennes brothers' oeuvre. In each reading, Pippin pays close attention to what makes these films exceptional as technical works of art and as intellectual and philosophical achievements. Throughout, he shows how films offer a view of basic problems of human agency from the inside and allow viewers to think with and through them. Captivating and insightful, Filmed Thought shows us what it means to take cinema seriously not just as art, but as thought, and how this medium provides a singular form of reflection on what it is to be human. (shrink)

The Persistence of Subjectivity examines several approaches to, and critiques of, the core notion in the self-understanding and legitimation of the modern, 'bourgeois' form of life: the free, reflective, self-determining subject. Since it is a relatively recent historical development that human beings think of themselves as individual centers of agency, and that one's entitlement to such a self-determining life is absolutely valuable, the issue at stake also involves the question of the historical location of philosophy. What might it mean to (...) take seriously Hegel's claim that philosophical reflection is always reflection on the historical 'actuality' of its own age? Discussing Heidegger, Gadamer, Adorno, Leo Strauss, Manfred Frank, and John McDowell, Robert Pippin attempts to understand how subjectivity arises in contemporary institutional practices such as medicine, as well as in other contexts such as modernism in the visual arts and in the novels of Marcel Proust. (shrink)

This is the first book-length study in any language to examine in detail and critically assess the second part of Kant's ethics- -an empirical, impure part, which determines how best to apply pure principles to the human situation. Drawing attention to Kant's under-explored impure ethics, this revealing investigation refutes the common and long-standing misperception that Kants ethics advocates empty formalism. Making detailed use of a variety of Kantian texts never before translated into English, author Robert B. Louden reassesses the (...) strengths and weaknesses of Kantian ethics as a whole, once the second part is re-admitted to its rightful place within Kant's practical philosophy. (shrink)

In this latest book, renowned philosopher and scholar Robert B. Pippin offers the thought-provoking argument that the study of historical figures is not only an interpretation and explication of their views, but can be understood as a form of philosophy itself. In doing so, he reconceives philosophical scholarship as a kind of network of philosophical interanimations, one in which major positions in the history of philosophy, when they are themselves properly understood within their own historical context, form philosophy’s lingua (...) franca. Examining a number of philosophers to explore the nature of this interanimation, he presents an illuminating assortment of especially thoughtful examples of historical commentary that powerfully enact philosophy. After opening up his territory with an initial discussion of contemporary revisionist readings of Kant’s moral theory, Pippin sets his sights on his main objects of interest: Hegel and Nietzsche. Through them, however, he offers what few others could: an astonishing synthesis of an immense and diverse set of thinkers and traditions. Deploying an almost dialogical, conversational approach, he pursues patterns of thought that both shape and, importantly, connect the major traditions: neo-Aristotelian, analytic, continental, and postmodern, bringing the likes of Heidegger, Honneth, MacIntyre, McDowell, Brandom, Strauss, Williams, and Žižek—not to mention Hegel and Nietzsche— into the same philosophical conversation. By means of these case studies, Pippin mounts an impressive argument about a relatively under discussed issue in professional philosophy—the bearing of work in the history of philosophy on philosophy itself—and thereby he argues for the controversial thesis that no strict separation between the domains is defensible. (shrink)

In the accompanying article contributed by Robert B. Lawson, proposals are made for revising the curriculum for doctoral students in biology in order to enhance a transdisciplinary awareness of biological science. The article is written mainly in the context of Dr Lawson's role as a scientist and educator in the United States. BioEssays will welcome articles along similar lines from educators in other countries. These should be sent to the Staff Editor, Dr Adam S. Wilkins.

Kant's anthropological works represent a very different side of his philosophy, one that stands in sharp contrast to the critical philosophy of the three Critiques. For the most part, Kantian anthropology is an empirical, popular, and, above all, pragmatic enterprise. After tracing its origins both within his own writings and within Enlightenment culture, the Element turns next to an analysis of the structure and several key themes of Kantian anthropology, followed by a discussion of two longstanding contested features - viz., (...) moral anthropology and transcendental anthropology. The Element concludes with a defense of the value and importance of Kantian anthropology, along with replies to a variety of criticisms that have been levelled at it over the years. Kantian anthropology, the author argues, is 'the eye of true philosophy'. (shrink)

In Overdoing Democracy, Robert B. Talisse turns the popular adage "the cure for democracy's ills is more democracy" on its head. Indeed, he argues, the widely recognized, crisis-level polarization within contemporary democracy stems from the tendency among citizens to overdo democracy. When we make everything--even where we shop, the teams we cheer for, and the coffee we drink--about our politics, we weaken our bonds to one another, and work against the fundamental goals of democracy. Talisse advocates civic friendship built (...) around shared endeavors that we must undertake with fellow citizens who do not necessarily share our political affinities as the best way we can obtain a healthier, more sustainable democracy. (shrink)

During the last decade of his life, Rorty emphasized the anti-authoritarian credentials of his pragmatism. He came to see pragmatism as the fighting faith of a second phase of the Enlightenment. The first stage, as Rorty construed it, concerns our emancipation from nonhuman authority in practical matters: issues of what we ought to do and how things ought to be. The envisaged second stage addresses rather our emancipation from nonhuman authority in theoretical matters. Pragmatism moves beyond the traditional model of (...) reality as authoritative over our cognitive representations of it in language and thought to a new conception of how discursive practices help us cope with the vicissitudes of life. Hegel anticipates the challenge to the very idea of objective reality as providing norms for thought that Rorty thought required us to enact a second phase of the Enlightenment. Unlike Rorty, Hegel presents a detailed, constructive, anti-authoritarian, nonfetishistic, social pragmatist account of the representational dimension of conceptual content. At its heart is an account of the social dimension of discursive normativity in terms of reciprocal recognition, and an account of the historical dimension of discursive normativity in terms of a distinctive new conception of reason: the recollective rationality that turns a past into a tradition. His idealism thereby offers a concrete pragmatist alternative to Rorty’s global semantic and epistemological anti-representationalism. (shrink)

The relationship between philosophy and aesthetic criticism has occupied Robert Pippin throughout his illustrious career. Whether discussing film, literature, or modern and contemporary art, Pippin's claim is that we cannot understand aesthetic objects unless we reckon with the fact that some distinct philosophical issue is integral to their meaning. In his latest offering, Philosophy by Other Means, we are treated to a collection of essays that builds on this larger project, offering profound ruminations on philosophical issues in aesthetics along (...) with revelatory readings of Henry James, Marcel Proust, and J. M. Coetzee. (shrink)

Important features of the self-concept can be located outside of the individual and inside close or related others. The authors use this insight to reinterpret data previously said to support the empathy-altruism model of helping, which asserts that empathic concern for another results in selflessness and true altruism. That is, they argue that the conditions that lead to empathic concern also lead to a greater sense of self-other overlap, raising the possibility that helping under these conditions is not selfless but (...) is also directed toward the self. In 3 studies, the impact of empathic concern on willingness to help was eliminated when oneness--a measure of perceived self-other overlap--was considered. Path analyses revealed further that empathic concern increased helping only through its relation to perceived oneness, thereby throwing the empathy-altruism model into question. The authors suggest that empathic concern affects helping primarily as an emotional signal of oneness. (shrink)

In Kant's Human Being, Robert B. Louden continues and deepens avenues of research first initiated in his highly acclaimed book, Kant's Impure Ethics.

The origins of pragmatism -- Pragmatism and epistemology -- Pragmatism and truth -- Pragmatism and metaphysics -- Pragmatism and ethics -- Pragmatism and politics -- Pragmatism and environmental ethics.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Kant's Theory of Virtue: The Value of AutocracyRobert B. LoudenAnne Margaret Baxley. Kant's Theory of Virtue: The Value of Autocracy. Cambridge-New York: Cambridge University Press, 2010. Pp. xvi + 189. Cloth, $85.00.Back in the early 1980s, Anglophone philosophers began to seriously explore the nature and role of virtue in Kant's ethics. This development itself was the result of a confluence of three other phenomena: (1) the growing influence (...) of virtue ethics within contemporary ethical theory; (2) the simultaneous publication of the first two complete English translations of Kant's important late work, The Doctrine of Virtue (Tugendlehre); and (3) repeated claims made by virtue ethicists that Kant had denied the importance of virtue for ethical theory.Anne Margaret Baxley's book, Kant's Theory of Virtue, is the most informative and comprehensive discussion of the nature and role of virtue in Kant's ethics currently available. Making careful use of the relevant Kantian texts (including not only Kant's published works but also lecture transcriptions from his ethics courses and some of his unpublished notes and reflections on ethics and religion), an important text by Friedrich Schiller (Über Anmut und Würde), one of Kant's early Romantic critics, as well as a wide swath of contemporary [End Page 142] secondary literature written by virtue ethicists as well as Kant scholars, Baxley demonstrates incisively that virtue, far from being neglected by Kant, is vitally significant to his ethical theory.Baxley's distinctive approach to Kant's conception of virtue is signaled in her subtitle: The Value of Autocracy. Autocracy—understood here as rational self-rule over sensibility—is, Baxley holds, "the overriding metaphor throughout Kant's treatment of virtue as a character trait, and it provides the key for understanding his particular conception of virtue" (52). This accent on autocracy results in a somewhat sterner Kantian virtue ethics than others have argued for. As Baxley herself notes, "[A]t first glance, autocracy looks as if it amounts to a rigid, repressive form of self-rule, one requiring the suppression or wholesale extirpation of sensible feelings and inclinations" (49). In an effort to show that first appearances are in this case deceiving, Baxley stretches the metaphor of autocracy (or, as she puts it, "reconstructs" Kant's claims about virtue) into the following three-pronged theory:[A]utocracy involves containing feelings and desires at odds with duty (the containment model), but it also involves maintaining feelings and inclinations to accord with moral concerns (the maintenance model), as well as cultivating feelings and inclinations that promote morally good ends (the cultivation model).(173; see also 126–36)Strictly speaking, however, when Kant himself uses the term ‘autocracy' (‘Autokratie') in discussing virtue (and he actually only does so once in his published writings—other terms such as ‘moral strength' [‘moralische Stärke'] and ‘courage' [‘Tapferkeit'] are used much more often), it refers exclusively to what Baxley calls the containment model, not the maintenance model or the cultivation model. Autocracy, Kant states in the Tugendlehre, "comprises a consciousness of the capacity to become master of one's inclinations that oppose the law" (6.383). Nevertheless, even if Baxley is asking the metaphor of autocracy to carry a bit more weight than Kant intended, her own reconstruction of Kant's theory of virtue is very well articulated and defended. And she is certainly correct in holding that Kantian virtue, correctly considered, entails not merely containing those feelings and desires that are opposed to duty, but also maintaining and cultivating those that are conducive to the moral life.Three important, interrelated aspects of her account that deserve highlighting are the following:Virtue and radical evil. Kant's account of radical evil, as presented in part 1 of Religion within the Boundaries of Mere Reason, forms an integral but underexplored component of his theory of virtue, and his belief in the existence of a universal human propensity to evil is the clearest example of how his understanding of virtue differs from the more familiar Aristotle-inspired accounts favored by contemporary virtue ethicists. As Baxley correctly emphasizes, on Kant's view virtue is "a corrective... to our propensity to evil... (shrink)

People live and age together in social groups. Across a range of outcomes, research has identified interdependence in the cognitive and health trajectories of ageing couples. Various types of memory decline with age and people report using a range of internal and external, social, and material strategies to compensate for these declines. While memory compensation strategies have been widely studied, research so far has focused only on single individuals. We examined interdependence in the memory compensation strategies reported by spouses within (...) 58 older couples. Couples completed the Memory Compensation Questionnaire, as well as an open-ended interview about their memory compensation practices. We found that internal, intra-individual memory compensation strategies were not associated within couples, but external, extra-individual strategies showed interdependence. Individuals’ scores on material/technological compensation strategies were positively correlated with their partners’. Reported reliance on a spouse was higher for men and increased with age. Our open-ended interviews yielded rich insights into the complex and diverse resources that couples use to support memory in day-to-day life. Particularly evident was the extent of interaction and coordination between social and material compensation, such that couples jointly used external compensation resources. Our results suggest that individuals’ reports of their compensation strategies do not tell the whole story. Rather, we propose that older couples show interdependence in their memory compensation strategies, and adopt complex systems of integrated material and social memory compensation in their day-to-day lives. (shrink)

Is King Lear against the blind? Must enlightened moderns find the play ethically objectionable? The portrayal of Gloucester in his blindness certainly relies on stereotyped attitudes that modern disability studies have made visible for us. Gloucester’s blindness is the physical equivalent of Lear’s madness, both representing the destruction of what would seem central to a satisfying human existence. Both are crucial to the structure of the play and its tragic impact, but, because Shakespeare gets right how various human beings respond (...) to Gloucester’s blindness, twenty-first-century readers and audiences can find both meaning and power in Shakespeare’s portrayal. (shrink)

For over a decade I have been arguing that Deweyan democracy fails an intuitive test for political legitimacy.1 According to this test, a political order can be legitimate only if the principles underlying its most fundamental institutions are insusceptible to reasonable rejection. Crucially, reasonable functions here as a technical term; a principle is reasonably rejectable when its rejection is consistent with embracing the ideal of a constitutional democracy as a fair system of social cooperation among free and equal moral persons. (...) From this emerges the corollary that a person is reasonable to the extent she seeks a political order whose basis is beyond reasonable rejection. The challenge for democratic theory... (shrink)

This paper is a critique of a paper by Robert Lipkin [1]. Arguments for the following claims are put forward: (1) that what is essential to the psychiatric relationship is what we want it to be for utilitarian reasons; (2) it would not be to our advantage to allow the medicalization of morality; (3) what we should expect from the psychiatrist is prudential advice, not moral advice, and that Lipkin has a confused view about the relationship between these two (...) areas; and (4) we should not allow the psychiatrist to restrict individuals on moral grounds, but only on public safety grounds. (shrink)

This fresh and original book argues that the central questions in Hegel's practical philosophy are the central questions in modern accounts of freedom: What is freedom, or what would it be to act freely? Is it possible so to act? And how important is leading a free life? Robert Pippin argues that the core of Hegel's answers is a social theory of agency, the view that agency is not exclusively a matter of the self-relation and self-determination of an individual (...) but requires the right sort of engagement with and recognition by others. Using a detailed analysis of key Hegelian texts, he develops this interpretation to reveal the bearing of Hegel's claims on many contemporary issues, including much-discussed core problems in the liberal democratic tradition. His important study will be valuable for all readers who are interested in Hegel's philosophy and in the modern problems of agency and freedom. (shrink)